He had tried everything but it made litt...

He had tried everything but it made little ____.

A．use

B．good

C．difference

D．result

C 【解析】试题分析：考查固定词组，make little difference意思“没有什么区别”，句子意思“他已经尝试过一切但是没有什么区别” 考点：考查固定词组

考点分析：

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