For some years the big drugmakers have been worrying about an approaching "patent cliff"—a fall in sales as the patents on their most popular pills expire or are struck down by legal challenges, with few new potential blockbusters to take their place. This week the patent on the best-selling drug in history expired—Lipitor, an anti-cholesterol pill which earned Pfizer nearly $11 billion in revenues last year.In all, pill like Lipitor with a combined $170 billion in annual sales will go off-patent by the end of 2015.
What is supposed to happen now is that lots of copycat firms rush in with "generic" (ie, chemically identical) versions of Lipitor at perhaps one-fifth of its price.Patients and health-care payers should reap the benefit.Pfizer's revenues should suffer. The same story will be repeated many times, as other best-selling drugs march over the patent cliff
But generics makers may face delays getting their cheaper versions to market.Ranbaxy, a Japanese-owned drugmaker, struggled to get regulators' approval for its generic version of Lipitor, and only won it on the day the patent expired.More importantly, research-based drug firms are using a variety of tactics to make the patent cliff slope more gently. Jon Leibowitz, chairman of America's Federal Trade Commission (FTC), is concerned by drugmakers filing additional patents on their products to put off the day when their protection expires.
Another tactic(策略) is "pay-for-delay", in which a drugmaker facing a legal challenge to its patent pays its would-be competitor to put off introducing its cheaper copy. In the year to October the FTC identified what it believes to be 28 such settlements. American and European regulators are looking into these deals. However, legal challenges against them have been delayed, and a bill to ban them is stuck in Congress.
To encourage generics makers to challenge patents on drugs, and introduce cheaper copies,
an American law passed in 1984 says that the first one to do so will get a 180-day exclusivity period,in which no other generics maker can sell versions of the drug in question, as Ranbaxy supposedly won with Lipitor.
However, Pfizer is exploiting a loophole(空子) in the 1984 law, which lets it appoint a second, authorised copycat—in this case, Watson, another American firm.According to BernsteinResearch, under the deal between the two drugmakers Pfizer will receive about 70% of Watson's revenues from its approved copy of Lipitor.More unusual, Pfizer has cut the price of its original version, and will keep marketing it vigorously. So Ranbaxy faces not one, but two competitors.
All this may raise Pfizer's sales by nearly $500m in the last half of 2015 compared with what they would otherwise have been, says Tim Anderson of BernsteinResearch, with revenues then falling after the 180 days are over. Others fear that Pfizer's tactics , if copied, will make the 180-day exclusivity period worth far less, and thus discourage generic firms from challenging patents in the first place.
1.The underlined word “blockbusters” in Paragraph 1 refers to “_______’
A. pills that sell very well
B. new patents to appear
C. drugmakers to compete with Pfizer
D. challenges which Pfizer has to face
2.What is the tactic mentioned in Paragraph 4?
A. Legal challenges against expired patents have been paid for putting off the cheaper copy.
B. Bills to prohibit generic makers have been stuck in Congress.
C. Drugmakers try to spend money delaying filing additional patents on popular pills
D. Patent-holders give possible competitors money to prevent more losses.
3.Pfizer exploit a loophole in the 1984 law mainly by ________.
A.marketing Lipitor more actively
B. making the price of Lipitor go up
C. cooperating with Watson to beat Ranbaxy
D. encouraging Watson to produce cheaper copies
4. How many tactics are adopted by patent-holders in the passage?
A. Two B. Three C. Four D. Five
5.Which of the following might be the best title for the passage?
A. Drugmakers’ struggle
B. Generic makers’ dilemma
C. Laws concerning patent protection
D. Popular pills of Pfizer
Concepts from science and nature are filled with our language’s common phrases , idioms and spoken expressions. The unbelieving expression “Well, I’ll be a monkey’s uncle” has its origin in bitter disbelief over Darwin’s writings on evolution. These colourful expressions bring spice(趣味) to our language.
Yet certain well-used phrases from science are just plain wrong! Some are obvious, yet we use them anyhow. For example, a person who acutely shakes her head and says “ A watched pot never boils” while you are waiting second after tiring second for test results to arrive or job offers to come in knows that if she sat down and watched a pot containing water on a stove over high heat for long enough, the water will eventually boil.
However, a few phrases have less obvious scientific inaccuracies. Here are a few for you to consider.
Once in a blue moon: This poetic phrase refers to something that occurs extremely rarely. A blue moon is the term commonly used for a second full moon that occasionally appears in a single month of our solar-based calendars. The problem with the phrase, however, is that blue moons are not so rare. They happen every few years at least, and can even happen within months of each other when the 29.5-day lunar cycle puts the full moon at the beginning of any month but February. The usage of “blue moon” as the second full moon in a month dates back to a 1937 Marine Farmer’s Almanac . But before that, blue moons meant something slightly different. Typically, 12 full moons occur from winter solstice to the next winter solstice, but occasionally a fourth full moon in a season could be observed . In such a case, one of the four full moons in that season was known as “blue”
Where there’s smoke, there’s fire: The phrase means that if something looks wrong, it likely is wrong. But let’s step back. Do you always have to have fire if you see smoke? Answering that first requires defining ‘fire” , Merriam—Webster’s first definition of fire is “ the phenomenon of combustion manifested in light, flame and heat”. Combustion is the chemical reaction that occurs when fuel is burned in the presence of oxygen---denying a fire any of these three things will stop the fire; attempting to start a fire without any one of the three things will be impossible. In complete combustion---what occurs when you light a gas stove--- the fire produces no smoke. However, when most materials are burned, they have incomplete combustion, which means that the fire isn’t able to completely burn all of the fuel . Smoke, then, can be considered to be a product of pyrolysis (高温分解) rather than of fire itself. You’re probably thinking---so what? To get the smoke, a fire needed to be present at some point, right? Not always.
Diamonds are forever: Thanks to the DeBeers slogan , decorating your honey’s neck, wrists and fingers with diamonds means true and timeless love. Of course, no object that you can hold in your hand can last forever. But diamonds have a special reason for being incapable of timelessness. Without the extreme pressures of the deep Earth where they formed, a diamond will slowly turn back into graphite(石墨), which is why the older a diamond is, the more inclusions it’s likely to have.
What common phrases push your buttons when viewed under the microscope of science? Are you curious about the hidden knowledge of some “ big” phrases ? Or perhaps you have the ability to uncover the secret of some unscientific phrases? Let us know!
1.According to the passage, the blue moon _________.
A. appears at the beginning of a month
B. gains its modern meaning before 1937
C. presents itself quite frequently sometimes
D. can never be seen by people in February
2.What can be concluded from the passage?
A. the older a diamond is, the more valuable it’s likely to be.
B. Fire is not necessarily causing smoke
C. Smoke is a product of complete combustion
D. the less obvious scientific inaccuracies of some phrases make them more useful
3. The underlined phrase “push your buttons” in the last paragraph means “_______”.
A. impress you a lot B. frighten you much.
C. surprise you greatly D. make you lose your interest
4. The author’s attitude towards the scientific inaccuracies of the phrases is ________.
A. indifferent B. objective
C. critical D. favourable
Money matters, no matter who or where you are. So when China’s currency the yuan was devalued (贬值) against the US dollar for three straight days in mid-August, the world felt the effects. As CNN put it: “If China sneezes, the world catches a cold.”
Why does it matter so much?
The exchange rate is the term for the comparison of two currencies. It says how much one currency is worth in terms of (换算) the other.
“Exchange rates play an important role in a country’s level of trade. It is one of the most important determinants (决定因素) of a country’s relative level of economic health,” wrote Jason Van Bergen of Forbes.com. A higher currency makes a country’s exports more expensive and imports cheaper, and vice versa (反之亦然).
Devaluation means the same amount of RMB can be exchanged for fewer USD. For example, on Aug 11, the exchange rate of RMB to USD was 6.23, which meant $1 was worth the same as 6.23 yuan. Two days later, the rate changed to 6.4, meaning the value of RMB had dropped by 2.7 percent.
So what does a weaker currency mean for our lives?
It first affects those who want to travel to, or study in, the US. If your former classmate is leaving for a preparatory (预科) school in the US at the end of August, it now costs about 1,800 yuan more to exchange currency for 10,000 US dollars than it did earlier this month. However, since many currencies have decreased in value, the value of yuan is still relatively high despite the recent devaluation. This means it costs 1,200 yuan less to get 10,000 Canadian dollars now than it did in March.
Even if we don’t have plans to travel abroad, though, we could still be affected. For example, your mother will have to pay more if she buys directly from overseas websites with US dollars. And chances are that imported chocolate and potato chips will soon be a bit more expensive in your local supermarket.
However, the weaker yuan is good news for Chinese exporters. It makes Chinese exports less expensive and it could boost the overseas sales that have been among the main reasons for China’s economic growth during its rise over the past 30 years.
Just as Erik Britton of Fathom, a London-based economic consulting firm, told The Guardian: “We’re all going to feel it: we’ll feel it through commodities (商品), not just from China but from everywhere that has to compete with it; and we’ll feel it through wages.”
“The devalued yuan will force China’s Asian rivals (竞争对手), such as Indonesia and South Korea, to compete even harder,” wrote Heather Stewart, economics editor of The Guardian. “The result may be cheaper Christmas presents.”
1.According to the passage, it can be learned from the passage EXCEPT___________
A. The higher China’s currency is , the less expensive potato chips from America become.
B. In March people spent 1,200 yuan more to get 10,000 Canadian dollars than they do today because Canadian dollars increased in value.
C. China’s currency’s devaluation against the US dollar in mid-August makes students studying in America pay more school fees.
D. People who work in Fathom will be greatly affected on account of the weaker yuan.
2.The passage implies that ___________.
A. The yuan’s devaluation contributes a lot to China’s economic growth .
B.Exchange rates are the most important factor determining a country’s relative level of economic health
C. The yuan’s devaluation has a great impact on all the countries in the world.
D.Chinese exports sell well overseas because of their high quality
3.If the exchange rate of RMB to USD increased from 6.5 to 6.7, how much more percent would you pay when you bought a bag worth $100?
A. 2.7 B. 5.4 C.20.0 D. 3.1
Masterclasses---Researching your novel
When it comes to fiction, research skills are as important as writing skills. Whatever your theme or setting, research skills are an invaluable resource for any writer.
On this course, novelist Alex Preston will show you how to use various research sources to write convincing , powerful stories. You’ll explore online horizons far beyond Wikipedia, and access vast resources of the un-sohuable.
Course description
Through a mix of talks and practical exercises, you’ll learn how to weave
professional-standard research into the fiction writing process to improve all aspects of your work.
Topics include
Resources for research ---using the Internet , libraries and media to enrich your story
Backgrounds---how to use your research to make your story interesting
Shortcuts ---how to research on a tight budget
Writing the past and the present --- how to use detail to bring the world of your story to life
Theories of research--- from Laurent Binet to Hilary Mantel, looking at how the masters work
Practical exercises--- a series of writing exercises designed to inspire and instruct
This course is for you if …
You are an experienced writer currently writing or planning a novel which requires more research than you’ve previously undertaken
You are a new fiction writer struggling with building a convincing world.
You are currently having plotting or structural problems with a novel
Tutor profile
Alex Preston is a prize-winning novelist and journalist. He appears regularly on BBC television and radio and writes for The Observer and GQ Magazine
Details
Date: 21 December 2015
Times: 10 am-5 pm. Check-in begins 30 minutes before the start time.
Location: The Guardian, Kings Place, 90 York Way, London N1 9GU
Price:
Early bird special￡199 ( limited in number)
Regular price ￡229
( all prices include VAT, booking fee, lunch and refreshments)
Event capacity: 16
Tickets may be paid back if you contact us at least 7 days before the course start date.
Book now and join our masterclasses ASAP!
1.If you want to make your story real and vivid, you should focus on “_______”
A. Backgrounds
B. Practical exercises
C. Resources for research
D. Writing the past and the present
2.The course is targeted at those who _________
A. are trying their best to work out ideal characters in a story
B. are popular writers with several works completed
C. write for famous magazines regularly
D. lack enough persuasive writing skills
3.Which of the following is Not true according to “Details” ?
A. Only less than twenty people can be admitted into the course.
B. The favourable price includes lunch and desserts.
C. Those who book in advance can get a 15% discount
D. The whole course lasts seven hours.
请认真阅读下面短文，从短文后各题所给的A、B、C、D四个选项中，选出最佳选项，并在答题纸(卡)上将该项涂黑。
Today the scientific community is in almost total agreement that the earth’s climate is changing and that this represents a huge threat to the planet and to us. According to a survey, with only 69% accepting the earth is warming— only 1 in 4 Americans see global warming as a major threat, public opinion ________ the scientific conclusion.
Climate scientists and campaigners have long debated how to better communicate the message to nonexperts so that climate science can be ________ into action. According to Christopher Rapley, the usual tactic(策略) of climate experts to provide the public with information isn’t________ because “it does not address key potential causes.” We are all exposed to the evidence of climate change on an almost a daily basis. The information is almost ___________.
Then what’s wrong? _______our brains.
Daniel Gilbert mentioned our brains’ failure to accurately notice gradual change. Robert
Gifford also _________the point about our brains’ difficulty in grasping climate change because of limited cognition and social ______ with other people (“Why should we change if X won’t?”) “ A more powerful barrier is the ___________ of perceived （感知的）behavioral control; ‘I’ m only one person; what can I do ?’ is certainly a big one. For many, the first challenge will be in recognizing barriers _____ they can overcome them”
But for those of us who understand that climate change is a problem yet make little effort
to cut the number of overseas trips we make or the amount of meat we consume, neither the uncaring attitude nor denial really explains the _________between our actions and beliefs. Lertzman has come to the conclusion that the conflict between ________ both the planet and our way of life is too painful to bear. “When we don’t ________ the pain of that, that’s when we get ______and can’t move forward.” Lertzman refers to this ________ as “environmental melancholia(忧郁症),” and points out that there’s a lot to be said for providing a means______ acceptable to talk about.”
Rosemary Randall suggests that climate change is such a(n) __________ subject that it “can raise fears and anxieties that people feel have no_________ in polite conversation.”
Lertzman says the community has been slow to realize the value of psychology. Gifford says otherwise,________—“ climate change, and not mental health, is the biggest psychological problem”
Despite the pain, shame, difficulty in fully addressing climate change, both Lertzman and Gifford are still _______ about our ability to face up to the challenge. “There can’t be anything about the human mind that stops us struggling with these issues , given that so many people ______ are — maybe that’s what we should be focusing on instead.” says Lertzman.
1.A. accounts for B. falls behind C. wishes for D. leaves behind
2.A. translated B. sprung C. forced D. sent
3.A. revolutionary B. detailed C. popular D. enough
4.A. unreliable B. unbearable C. unacceptable D. unavoidable
5.A. Submit B. Control C. Blame D. Curse
6.A. picks up on B. gets down to C. throws back on D. looks up to
7.A. connections B. comparisons C. competence D. development
8.A. sense B. problem C. lack D.effect
9.A. if B. though C. before D. since
10.A. relationship B. disagreement C. gap D. balance
11.A. caring about B. taking on C. fighting against D. putting away
12.A. feel B. process C. remember D.hide
13.A. hit B. puzzled C. stuck D. stressed
14.A. conflict B. event C.hesitation D. inability
15.A. socially B. environmentally C. culturally D. morally
16.A. complex B. controversial C. awkward D. disturbing
17.A. idea B. goal C. place D. choice
18.A. somehow B. however C. therefore D. either
19.A. optimistic B. concerned C. cheerful D. encouraged
20.A. equally B. still C. especially D. already
—I just can’t believe that Ella the cat has left me forever.
— ______ and cry. Don’t hold it in.
A. Don’t worry B. Go ahead
C. Forget it D. Help yourself
