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his knowledge of the mountainous village...

      his knowledge of the mountainous village, John was appointed as our guide.

A. In spite of  B. On account of

C. Regardless of D. Instead of

 

B 【解析】 试题分析:考查介词短语的辨析。In spite of虽然,尽管…;On account of考虑到,基于,由于;Regardless of不管,不顾;Instead of代替,而不是。句意:考虑到他对乡村知识的了解,John被任命为我们的向导。故选B。 考点:考查介词短语的辨析  
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